Her Earthly one is Andrew, while her Devil rival is Sulfus. She shares her thoughts and worries with a secret diary. She's the leader of the group Angel's Friends. In the cartoon, she is 15 'stars' old, and she's curious and lively, practical and rational, romantic and caring.

Her mascot is the ladybug Cox, who becomes the pendant of her necklace. She has long blond hair, big blue eyes, pink wings, and a halo. She loves cooking and herbal medicine and is in love with the Earthly one Raoul. She organizes the concerts of the band Angels, in which she is the vocalist. She is steadfast, loyal, brave, and imaginative, but stubborn and reckless. In the comic, she lives with her mother in a big house in Angie Town and is 12 stars old. To realize the animated version of Raf and Sulfus, creator Simona Ferri looked at Avril Lavigne and Bill Kaulitz as models.

The comic, published two years before the broadcast of the cartoon and then discontinued, had far younger characters and Angels and Devils not shown in the animated version. Reina makes Raf and Sulfus fall in love and kiss: the sacrilege committed frees her, so that Reina can try to take revenge on Angels and Devils. Reina is imprisoned in the Limbo by High and Low Spheres because she tried to force her Earthly one to love her. The first season antagonists include a Neutral being, Reina, and her servant Maliki. The Angels, called Angel's Friends, are led by the main character, Raf, and are composed of her three friends Uri, Miki and Sweet, while the Devils, called Devil's Enemies, are led by Sulfus and are composed by his friends Kabale, Cabiria and Gas. Angels come from Angie Town and are ruled by the High Spheres, while Devils are from Sulfur City and are ruled by Low Spheres. The series takes place in a fictional town, where four teenage Angels and four teenage Devils, are attending the Golden School to learn the art of being Guardian Angels and Guardian Devils, guarding and tempting the human beings, called Earthly ones. The Angel's Friends comic and cartoon series features a cast of characters designed by Giada Perissinotto (comic) and Igor Chimisso (cartoon).

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